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KMID : 0363220080460050652
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Korean Journal of Dermatology
2008 Volume.46 No. 5 p.652 ~ p.655
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A Case of Dohi Presenting with Diffuse Pigmented Patch on Both Dorsum of Hands
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Kim Sang-Min
Oh Byung-Ho
Lee Yang-Won
Choe Yong-Beom
Ahn Kyu-Joong
Song Kye-Yong
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Abstract
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Reticulated acropigmentation of Dohi (RAD), dyschromatosis symmetrica hereditaria, is the localized acral form of
dyschromatosis universalis hereditaria that has an autosomal dominant pattern of inheritance. RAD is characterized
by the mixed hyperpigmented and hypopigmented macules and its bilaterally symmetrical distribution on the back of
the hands and feet, wrists, knees, and elbows. The presented case is a 18-year-old female had relatively well demarcated symmetric hyperpigmented and hypopigmented macules and patches on dorsa of hands and feet, forearms, lower legs and face. These pigmentations at first appeared at 3 years old on dorsa of her fingers and toes, thereafter these pigmentations spread progressively to the proximal portion of her body. Her pedigree shows autosomal dominant pattern of inheritance. Histologically, there is markedly decreased basal pigmentation with preserved melanocytes. Immunohistochemical stain for the Melan-A revealed both areas of either decreased or increased Melan-A positive melanocytes in basal layer, which suggests that Reticulated acropigmentation of Dohi is a genetic disorder of functional derangement of melanocytes. (Korean J Dermatol 2008;46(5):652∼655)
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KEYWORD
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Acropigmentation, Hyperpigmentation, Hypopigmentation
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